This is a big deal when resistance can jump 30 or more points from a single act and you're not checking resistances on a first playthrough. The in-game text suggests that it's repeating actions that increases resistance, when in reality it's just repeated exposure to the serums. The balancing between influence and resistance gains seem to be way off.
Even using the skip feature as much as possible it takes close to an hour to play through all 125 days. That means you could easily see all content for a character well before reaching the 100 influence needed to see their ending. Using a blue serum you can have sex with any character, and threesomes where available, once their influence is over 60. Most notably, there is no indication of how high influence needs to get for a particular ending. This feels like a very complete game with only a couple areas where missing content is noticeable.
I did have a lot of fun playing this and enjoyed the look of the characters, which is quite important with 3D.
Came close my first playthrough, but stopped around the 90s when I ran out of content for her and didn't know it had to be over 100. Played through a few times over the past couple days and got everyone except the mother fully influenced.